The Dual Role of ROS and Antioxidants in Health and Disease
Dra. (MD) Monica Cristina Carrasco
Universidad de Carabobo, Venezuela
Keywords: Reactive oxygen species, oxidative stress, antioxidants, redox homeostasis, cell signaling, antioxidative stress, personalized therapy
Abstract
Reactive oxygen species (ROS) are key players in cellular processes, acting as both damaging agents and vital signaling molecules. The balance between ROS production and antioxidant defenses is essential for maintaining cellular homeostasis and preventing oxidative stress. This review explores the dual role of ROS, emphasizing the paradoxical effects of ROS in both promoting cell survival and causing cellular damage. It also examines the mechanisms of endogenous antioxidant defenses and the impact of excessive antioxidant supplementation, which may lead to antioxidative stress. By analyzing the pathways that regulate ROS production and detoxification, this paper highlights the importance of personalized strategies in managing oxidative stress and optimizing redox homeostasis.
Author Biography
Dra. (MD) Monica Cristina Carrasco, Universidad de Carabobo, Venezuela
